@krag1949 Since this is a newer diagnosis and about 6 months on the HU, your doctor may consider adjusting your dosage as your elevated blood numbers decrease. Sometimes reducing the meds can still keep the blood cells to a more normal level while still being therapeutic.

Have you mentioned your increased pain level to your hematologist? How have your blood counts been? Has the HU been successful in lowering and controlling the platelets and WBC?