I neb once a day and have 4 Pari eRapid handset sets. After each use I take apart the handset and rinse every part under hot tap water, then put them in a mesh colander/bowl with a lid (to keep my cats from fishing out the blue silicone valves, which they think are toys) to dry. On the fourth day, after rinsing as usual, I soak the aerosolizing mesh parts in soapy water for 5-10 minutes while I bring a pot of distilled water to boil. I rinse off the soap, put the mesh parts back with everything else, dump the lot into the boiling distilled water and simmer for 11 minutes. Then I remove everything with tongs and place in a bottle sterilizer I use only for drying, and use the 40-minute dry cycle.

I replace the distilled water every 1-2 weeks.

Until recently I used 2 handsets and boiled every other day; I'm just starting this every-4-days system. So far I am relieved to only have to boil half as often. I'm clawing back time wherever I can.