Quick update. Still on the Merck trial (control) but have had to ups my dose of Jakafi to 15 mg/2x/d as the 10 mg/2x/d was not helping. Hoping to get on the JNJ-88549968 trial soon. This treatment may be one of the best options to a cure for the CALR mutation. Incyte is also starting trials with a similar mode of action.
https://www.ctsearchsupport.org/clinical-trials/a-study-of-jnj-88549968-for-the-treatment-of-calreticulin-calr-mutated-myeloproliferative-neoplasms