"A opposed to administering the 5 mg of zoledronic acid in 100 mL of D5W and infusing it over 15 minutes, for the past 29 years I have had the infusion nurse at Stanford dilute it into 500 mL of NS, and to infuse the 600 mL of now diluted BP over 60 minutes. TRUST ME!! By diluting it and administrating it more slowly, it improves the renal (kidney) safety.
The other thing I do is to instruct the infusion nurses to give the patient 650 mg of acetaminophen (Tylenol) during the infusion. Then I tell the patients to take that same dose (two regular strength tablets) with dinner and at bedtime the day of the infusion, with all 3 meals and at bedtime the day after the infusion, and a final (7th) dose with breakfast the 2nd morning after the infusion. This reduces the patient's risk of experiencing a symptomatic APR from >28% to < 1%."
endodoc
It might be difficult to get any of this without your doctor ordering it this way. You might brave it concentrate on taking your own tylenol and hydrating on your own. This Stanford doctor clearly has control of the infusion clinic. But I think without orders the clinic wouldn't be able to dilute the infusion. You might delay the infusion until your doctor can write the order. (I mean to say that I would) On the other hand you may have no trouble with the infusion.
Best wishes