@jesslily you take it every day. It took me about two months to work up slowly to a dose that started to minimize symptoms. You cannot take LDM if you regularly need pain medications as it blocks the receptor and you will not get pain relief. For me, my inflammation, pain, shortness of breath, skin breakouts, fatigue and more have all minimized and it has gotten better as I raised the dose. I am now at 5 mg per morning and have more energy and ability to do things than I have in 6 years.