I had Orgovyx prescribed about 8 weeks in advance of SBRT (5 sessions). I have cribriform (3+4). I am 64, gleason 7 with cribriform in 2 tumors, gleason 6 in 4 tumors - surgery vs. radiation werequipoise per my oncologists and 2 second opinions at MSK and Smilow). I remained on Orgovyx for another 8 weeks or so. About 16 weeks in total for Orgovyx. As soon as I started the Orgovyx I was advised to maintain a routine exercise schedule. This helped A Lot! The radiation (barigel spacer in place as well) came with some fatigue that was entirely manageable. All done as of late February with undetectable psa and pretty close to normal in all other areas (still using flomax and some occasional fatigue).