Hello, dd1949! For some people, HU works quickly, lowering their platelet count and keeping it down.

For others -- like you and me -- it takes much longer, and there's some bouncing up and down in the bloodwork.

And as nohrt4me has commented, platelet counts vary from day to day, even from hour to hour.

As for feeling tired -- lots of us share that too. Be patient with yourself. Rest when you need to.

You're making great progress!