I started Verzenio with 50mg (100mg per day), increased to 150mg per day after 6 months, and now at 100mg (200mg per day) after 9 months. I tolerated it well, only a couple of incidents of diarrhea. My oncologist recommend increasing the dosage because the studies used for Verzenio approval were done at 150mg(300mg per day). Although there are publications saying that it is still effective at lower dosages.