@narelled23 Thank you for your reply. I’m new to this site, but really enjoy the questions, replies and compassionate people. My issue is more in the bottom of my whole feet and all toes and at times in my lower legs. I know it’s a likely symptom of COPD. I have mild to moderate COPD and also multiple nodes, unfortunately an 8mm and a 10mm on my diaphragm that’s too dangerous to biopsy. I had C scans and just started PET scans. But keeping a positive attitude. Thanks again. Arthur