@kherman8434 @lizr5678
As a bc patient myself I totally understand your decision. I couldn’t tolerate full dose of anastrozole so my onco switched me to exemestane. I tolerated much better but decided to skip one day a week to lessen aches and pains ( not telling my onco) I found this article about taking exemestane three times a week is non inferior to taking every day. But since I can tolerate exemestane daily, I haven’t started yet.
https://dailynews.ascopubs.org/do/reduced-dose-exemestane-noninferior-standard-daily-dose-postmenopausal-women-early-er
I wonder why there is no study of lower dose for anastrozole, especially the half life is 50 hrs?
However, I also found an article suggesting old patients being overexposed to AI could develop renal impairments. The article suggests further research but I guess there is no agency decided to follow up, definitely not pharmaceutical co.
https://aacrjournals.org/cancerres/article/75/9_Supplement/P1-12-15/606865/Abstract-P1-12-15-Intermittent-dosing-of-aromatase
In the meantime we just have to do what we think best for us. Living with intolerable aches and pains is not living at all. Besides there is no guarantee the cancer won’t come back if we take full dose. Wish you all the best.