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GLP-1 Drugs Causing Arrythmias
Heart Rhythm Conditions | Last Active: Aug 3 11:15am | Replies (70)Comment receiving replies
@merrychristmas I am well aware of all the potential benefits for sleep apnea, afib, hypertension, etc (both on label and off label benefits) Forgive me but that’s not the point. The point is I developed afib 3 weeks after starting Zepbound, out of the blue. Bad enough I was in the ER for a day.
My interest is in reports of afib induced early into starting Zepbound. Granted, as I lose weight, the stress on my heart will be reduced and the afib disappear.
GLP1’s affect the autonomic responses to hunger and satiation, but autonomic responses for heart rate and rhythm are also affected by GLP1 receptors. Is there a possible temporary negative crossover effect? That’s my question.
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@pbd67 ouch
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@pbd67 I can't say definitively, but the Vagal response or tone is well established as a factor in some cases of AF. GERD and stomach distension are known triggers, as are electrolytic defects. So, it's entirely conceivable that the GLP-1 has acted as a trigger. Did it 'start' or bring on your AF? Almost certainly not; your AF was waiting for an excuse, and it came. Neither of us can prove it, but if you were to cease the GLP-1 and never had another round of AF, that might be a great clue. If you do that, and then try GLP-1 for a couple of doses, and you get the AF, that would be strong proof that it is a trigger...but your AF is still 'there'. This is my opinion...for what it's worth.