@1hostahoney I have PV JAK2 positive and take Hydroxyurea also. My doctor wants to increase to lessen phlebotomies. Currently every 8-10 weeks to keep numbers in check but it gives me too much tooth nerve pain and extreme sun sensitivity if I take too much. So she wants to switch me to Jakafi to lessen phlebotomies also. BUT there is a new drug that should be coming out by end of this year called RUSFERTIDE? It tricks the bone barrow into making less cells which lessens and sometimes eliminates the need for phlebotomies . Look it up. I’m waiting for it.