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Vitamin K: High Doses of MK-4 and MK-7 Show Promising Results

Osteoporosis & Bone Health | Last Active: Jun 6 10:56pm | Replies (107)
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@singingbones For a couple months, I've been taking: 180mcg Menaquinone-7 (MK7) - TrueVantage brand and 45,000 mcg (45 mg) of vitamin K2 (menaquinone-4) - Life Extension K2 High Potency brand.

I am considering switching to a MK4 supplement that comes in three 15mg doses, but they are a lot more expensive than those that come in one 45mg dose. I know that's what was used in the Japanese studies. However, I read this article: https://threearrowsnutra.com/blogs/ironwarrior/mk4-vs-mk7
It says: "MK4's serum half-life is roughly two hours — and that rapid disappearance from blood isn't a weakness. It's the opposite. Your body pulls MK4 straight into the brain, bone, kidney, pancreas, and reproductive organs. What leaves the bloodstream fastest may be doing the most work. If a nutrient's invisible in a blood draw, it's often because it already reached where it needs to be."

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Replies to "@singingbones For a couple months, I've been taking: 180mcg Menaquinone-7 (MK7) - TrueVantage brand and 45,000..."
singingbones | @singingbones | Apr 30 1:43pm

@daisy17 - I've been taking MK7 for several yrs in addition to other supplements. AI seems to think that taking MK4 (divided doses) while on Evenity would be safe because they behave differently (how's that for a technical summary?). I have not found any studies except for one that speaks to taking MK4 while taking a bisphosphonate. I reluctantly agreed to the Evenity (not a bisphosphonate) course, which I will finish in 2 mo.

Interestingly, I did take strontium citrate for 2.5 months before Evenity, but had not studied it enough to proceed after the dr was adamant about the drug.

At this moment, I plan to add the MK4 at the end of the Evenity drug, as it seems more sensible and then eventually to transition to strontium citrate to maintain the gains. I haven't found anything that would indicate that MK4 could hold the density gains, but I'm still digging!

I suspect that bone turnover markers will be good indicators while waiting on the 2-yr DXA period offset by REMS scans in between.

Very interesting article that you cited - thanks!

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