I don't know if this has been discussed previously and, if so, I apologize for my redundancy. I just read an article in a health column this AM about neuropathy and it's causes - which know one really knows that answer. There are lots of guesses, but nothing definitive yet. However, the one learned item for me is that exercise and good blood sugar management can reverse the effects. Mine is mostly during the night when I am not moving, but there are a few things we can do to alleviate some of the effects.