Yes. For decades my doctors would put me on different statins, different doses and I had horrible side effects, I thought I would have to quit working and go on disability from taking those drugs. I was not willing to have a horrible life just to lower cholesterol. I would rather live less years happy than more miserable. My life was ruined. I tried Repatha. Same thing. I am now on Nexletol for 6 weeks without side effects so far. I was VERY skeptical because of the many years with bad side effects. I am still skeptical but taking it one day at a time. I can gauge my strength at yoga. How easily can I do poses and how long can I hold them? Right now the answer is that yoga is going great.