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bikeman1 avatar

Low, But Rising PSA--Wait for Imaging or Act Now?

Prostate Cancer | Last Active: May 11 3:56pm | Replies (72)

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Profile picture for heavyphil @heavyphil

I have always found Dr Kwon’s approach unsettling. If standard SRT to the bed and nodes is to be frowned upon, why then do so many men - including myself - see a dramatic DROP in PSA levels after treatment?
Surely, if there is undetectable cancer in soft tissue outside the traditional area of treatment, the radiation (with ADT in my case) would not affect it and PSA levels would be expected to rise…they don’t!
I’ve read of the different ways metastasis occurs - and they are all based on extremely complex (like paragraphs of Greek letters) mathematical formulae. The ‘stochastic’ model is bewildering to comprehend.
I have heard that pancreatic cancer spreads this way, in that once the tumor reaches a certain size, it is considered inoperable, as it has already micro - metastasized everywhere; which is why it is so deadly and carries such a high mortality rate.
But prostate cancer doesn’t - cure rates (long term remission) are incredibly high, so again, I wonder about Dr Kwon’s assertions.
Don’t get me wrong, he’s the expert, he’s the genius and his many papers prove his vast knowledge in this field, but with your pathology I personally would not waste any time in getting SRT with ADT. Your cancer has many factors which make it more aggressive.
Just my layman’s opinion, not medical advice.
Phil

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Replies to "I have always found Dr Kwon’s approach unsettling. If standard SRT to the bed and nodes..."

@heavyphil Just to add, there ARE cases where the horse has left the barn, as evidenced by recurrences many years down the road, but they are not the norm.
I think members of this forum are exposed to a LOT more of these delayed recurrences simply because we’re ON the forum, not one of the millions walking around (or deceased) never having had a meaningful relapse and therefore have no need to be here.
Phil

@heavyphil
"I have always found Dr Kwon’s approach unsettling. If standard SRT to the bed and nodes is to be frowned upon, why then do so many men - including myself - see a dramatic DROP in PSA levels after treatment?"

That is exactly what I told my husband the other day. So many studies show high advantage of having sRT and not only having it but with exact cut off number for great success (before PSA 0.5, and the BEST before 0.25 ) - so in what way waiting can be beneficial ?

If one listens carefully to presentation there is one place where doctor says that "for one third of patients there will be no benefit" - which means that for 2/3 it will ! I think that 66% of benefit outweighs 33% with no benefit. Missing about 30% chance of perhaps even being cured is not something that my husband and me are willing to gamble away, SA or not.