@jenelleseaman CA 125 is also a marker used in the detection for serous uterine her2+ cancer.
I am on a maintenance treatment with a targeted chemo called enhertu. It is fairly new in treating my cancer, approved in summer of 2024. I have a 30 minute infusion every 4 weeks and prior to treatment my blood is drawn and CA 125 is monitored. It elevated twice since my initial diagnosis in April 2021...stage 1A total hysterectomy...brachytherapy 3 times and then followup every 3 months with survivorship nurse...no blood drawn! In 2022 after much stomach bloating and being told it was classic IBS, which I never had, after a CT scan cancer had recurred and CA125 was 400. After 6 rounds of carboplatin and herceptin my CA 125 was normal under 35. Scans were clear until April of 2025 after slow trending up of CA 125 from 15 to 70 over 6 months and no symptoms, a PET scan showed very small activity in 2 pelvic nodes. I began infusions of enhertu on May 7, 2025...After 2 treatments CA 125 was in normal range at 25....has remained between 13-16 since July 2025. I had an infusion today and my CA 125 was 14 ! For me my cancer is very sensitive to CA 125 and I do not have ovarian cancer, but it is closely related...perhaps because it is her2+....all of this to clarify that CA 125 is used as a marker for more than ovarian cancer ...best of luck to you !!!