@okiebon Sorry to be so late in responding. I don't check mayo connect daily. During quad treatment, iI had dexamethasone 2 days per week and did not sleep at all on the mornings I took dex. It took about 2-3 days to get back to a regular sleep pattern, and about the 3rd day after taking it was a "crash " where I had low energy. Post SCT, my infusion and injection and dexamethasone is 1 day per month. Still up all night the day I take it but better after day 2. Hope you are doing well.