@klm1235567 I’m 72 and was Diagnosed three years ago with PV and take 500mg Hydroxy urea and 81mg aspirin daily. Phlebotomy is taken if Hematocrit number is 45 or higher. I’ve not had one for two months. Seems the medicine is working fine. Yet told I now have low iron as a result of phlebotomies in the past. Was having one maybe every month then went every other month during these three years. Yes fatigue is part of this cancer. A nap every day helps. My concern is the doctor wants me to stop my HU medication and start Jakaf. Concerned as to why if the HUrea is keeping my Hematocrit number down. Said I could never stop cold turkey the Jakaf once started. I would have to wean myself off it. Sound scary and from the others who’ve taken Jakaf it doesn’t help with fatigue. Think I will talk to doctor and express I’m not wanting it and stay on HUrea a few more months hoping it will keep number under 45. Will anyone want to suggest or comment their experiences with why changing meds is necessary?