How to Quit Pantoprazole?

Posted by ksdm @ksdm, Mar 16, 2025

I have been on Pantoprazole for the last two months to combat the acid stomach I got from taking pain meds. I am feeling good now and want to know how to stop taking this drug. I still feel a little acidy when I wake up but couldn't I take something else for that?

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Profile picture for jonimars26 @jonimars26

Hello- I was told I had gurd several years ago but I never went on any medication. I tried to make better diet choices and mostly avoid spicy and fried foods which bothered it the most. Just recently tho it got worse and I agreed to take pantoprazole for 30 days. I have been on it for 10 days and have been experiencing rapid heartbeats several times a day. Has anyone experienced this? I did read that it can be a rare side effect. I am discontinuing the meds and don't think I need to taper off since I've used it for such a short time. Any thoughts?

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@jonimars26 I had pretty bad palpitations from pantoprazole and worse from omeprazole. The other side effects from both were so bad I was not able to stay on either one for any length of time. The stomach pain and bathroom issues were too much to handle. I ended up taking famotidine for four months to help the silent reflux. My voice changes and cough finally went away but only for a month. I’m hoping to have better luck with lansoprazole. My doctor says PPIs are the only thing that will get rid of the silent gerd problems for a longer period of time. The H2 receptors just are not as effective.
Sorry, I’m long-winded… I think after only 10 days you will not have a problem stopping the pantoprazole. I tried it for longer than that and was fine stopping. You may have different experiences with other PPIs, so don’t give up! I was only able to take a certain brand of famotidine because the fillers of some brands made me nauseous and sickly. These medications are such a pain! Good luck!

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Profile picture for casey1959 @casey1959

@jackielb Are those 2 meds also pump inhibitors? Im concerned for husband being on Pantoprazole! Yet surgeons say he needs it. Just had the Whipple on 4/13.

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Hello @casey1959

In my experience (after three digestive tract surgeries), using a PPI after digestive tract surgery is important. It helps with the acid level.

It looks like your husband had the Whipple just 10 days ago. How is he doing post-surgery? Also, how are you doing?

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Profile picture for carolinlv @carolinlv

I was taking pantoprazole for over three years for Gerd and all the uncomfortable symptoms associated with it. The pantoprazole was a dream, until it wasn’t. I had lower stomach pain that would not go away. I still had no symptoms of Gerd, but my doctor was thinking possibly the pantoprazole had changed in formula. Evidently, the non-active ingredients in a med can be changed randomly. He had multiple patients complain of stomach pain and we were all taking pantoprazole. He didn’t think it wise to take me off an antacid completely so he changed me to omeprazole and the same thing happened. Guess that wasn’t my problem. We finally decided I had been on it so long, maybe I didn’t need it any longer, so I stopped taking it. That was four months ago. I’ve needed an occasional dose of Mylanta or Tums, but that was it. Well, this week I have started to have some Gerd symptoms again. I’ve woken up a few times in the middle of the night with nausea and a headache. I’ve had difficulty sleeping, which is not all that odd for me, but waking up at 2:30 and unable to go back to sleep at all. Now I’ve got the stomach discomfort again. Has anyone stopped taking a PPI because it was making you as sick as the illness you were treating? I have read Gerd returning is common, but these symptoms are slightly different. I don’t have heartburn. I have all this other middle of the night stuff instead. I’m afraid to start a PPI again, especially after reading so much about them when I stopped. I have read you can take them for 6 to 8 weeks 3-4 times a year to heal esophageal problems. Has anyone ever done this type of short term treatment? I can handle a lot, but I have to have at least five hours of sleep. Right now, I’m lucky to get that. Just in case anyone has this thought, I had an endoscopy in February of this year, so I don’t think it’s anything serious unless it’s something that came on quickly. I was prescribed medication to heal a very small ulcer that was found, which was also meant to heal the minor Gerd symptoms noticed. Any thoughts out there?

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@carolinlv I too took PPIs for 3 years and it depleted my magnesium so bad I was in danger of a heart attack or stroke. I went to the hospital with numbness and inability to use my left arm. I was critically low in blood magnesium, potassium, and calcium which I had to get via IV for 2 days. They took me off the PPI (protonix) and put me on 20 mg famotidine (pepcid/zantac) and I take an occasional tums. I have stomach inflammation, which complicates things. GERD never goes completely away. It can be managed, but the over the counter stuff is better. PPIs can be dangerous for some people on long term use. I eat small meals; less meat, more nuts and beans and legumes and hard cheeses; less sugar aiming for no sugar; more fruits and vegetables, cooked when I have a flare up; DeLallo imported whole grain pasta that has one ingredient, whole semolina wheat, which I stop with a flare-up; only 1 cup of milk per day to maintain my calcium levels along with the hard cheese. I do not eat many spices, and no garlic, onion or other alliums, only freeze-dried chives. I also don't eat and only drink water after 7 pm. I drink 2 liters of water a day. I have been able to manage the inflammation that causes my GERD. I keep 100 mg Magnesium Glycinate on hand and when my toes or feet start cramping, I take one and notify my PCP who orders a magnesium test. Oral Magnesium causes diarrhea in me, so if too low, I get an IV infusion in the emergency room and then go home. You are right to be afraid of PPIs. Change your diet, avoid acidic foods to prevent another ulcer, which probably caused the original symptoms, but you have to control the acid levels and inflammation that causes ulcers. Barring PPIs, changes in your diet and talking with a pharmacist about which of your medications may also be causing inflammation could help you with your nighttime symptoms. Alternatives might be available that a pharmacist could recommend.

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