@1995victoria you can read papers on the topic and get the nuances of the work yourself there is some evidence that some patients with JAK mutation may see a reduction in the mutant JAK allele with interferon treatment. Some people have reported significant reductions in their JAK mutant allele levels, others less so or none. There is less evidence, but some, that it could work on one of the other mutant alleles. It is an interesting treatment option. You should talk to your hematologist.