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@brianjarvis ❝PSMA PET scan results will typically show little while on ADT. The lower the PSA, PSMA PET will be “essentially negative.”❞

Yes, that's part of why I'm not getting PSMA-PET right now for routine monitoring. With my PSA undetectable (< 0.01) on ADT+Apalutamide for 4.5 years, it might not show much. Instead, I get a combo of bone scans, CT+contrast, and MRI+contrast, all of which could show growths regardless of whether they express PSA (and even, god forbid, if they're a different type of cancer developing), even though the resolution is a little coarser.

(The other reason is that PSMA-PET is used much more sparingly outside the U.S., since there's little evidence yet that it improves overall survival or progression-free survival, despite its finer resolution. I could ask for one if I had biochemical recurrence — my PSA started rising again — but it's not a routine thing.)

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Replies to "@brianjarvis ❝PSMA PET scan results will typically show little while on ADT. The lower the PSA,..."

@northoftheborder Another possible option —> If a PSMA PET scan is negative or equivocal, Axumin (18F-fluciclovine) is an imaging option. When prostate cancers lack PSMA expression, Axumin may detect tumors that PSMA misses.

I attended a webinar last year that was out of Australia. The speaker mentioned that Axumin is commonly used in these situations. (And I’ve read that Mayo Clinic uses C11 Choline PET CT in these instances.)