I am on lenalidomide as a maintenance program and was on it for my initial pre-transplant drug induction. The fatigue has been manageable for me. The primary side effect I have is severe constipation. Having said that, my oncologist felt the constipation is from the Darzaflex, though I am only on that 1x/month now and received it more often during drug induction. My maintenance program started in February. Good luck.