@annedallas Everyone with CLL has a compromised immune system, so infections (like colds, sinus infections, etc.) are common. If the IG(g) level falls a lot and you’re getting infections, you might be helped by IVIG infusions)I get them quarterly). As noted earlier, everyone is different. If symptoms appear, you’ll know it—and consult your medical team. Just live your life and try not to worry too much about it. I’m 20 years in, travel internationally extensively (typing this in China), and have been taking ZANUBRUTINIB for nine years. It doesn’t have to change your life!