@jago
I think you were very wise to send in a sputum to check for an infection with your increase in symptoms. Hope you are feeling better. I've been on Brinsupri for 6 months now. I've found it takes time for this medication to fully "kick in" . I had ups and downs with it and wondered at times if it had stopped working also, but continued with taking it and the grinding routine of airway clearance. Now, I am thankful I did and did not stop taking it. The difference in my lungs is remarkable. Hang in there.