@surftohealth88 I haven't read in detail yet (just the summary), but I suspect the cancers that get by ADT+ARPI would be the very nastiest of them, so it makes sense you'd see a bigger ratio of nasty cancers.

It's like if the water bombers put out all the smaller forest fires, you're left with a bigger percentage of large fires.

But again, I'm not an expert, and just exploring possibilities. Restrospective studies of other studies' data are useful for showing where researchers should look next, but in themselves, they're relatively unreliable: more about asking questions than providing answers.