Hi Cathy, my pre-Tymlos P1NP was 67 and it jumped to 250 at the 7 week mark.
At the 6-7month mark the side effects on the full dose was really getting to me...lots of random roving bone pain mainly in my limbs, muscle weakness. I am small so dropped my dose to 0.6mcgs and the effects largely went away in two days. When I tried to go back up to the full 0.8mcg dose the came right back. I went back down to 0.6mcgs, stayed there for week-10 days, had another P1NP and CTX drawn on my own and they were still showing fab response (P1NP was now 358) so I went to my doc and he blessed the lower dose. At the 1 yr mark my DEXA was really great... am out of osteoporosis and back into osteopenia. P1NP is starting to come down (289 at 1 yr mark). I am putting this info out there because I think it's a great drug (for people who respond to it) with great promise and hate to see folks abandon when even a slightly lower dose could mitigate the side effects and still give them good results. Radius can't acknowledge this because their testing has been at the full dose. Talk to your doctors! Advocate for yourself! And think about HRT and taking Fortibone collagen! I use AlgaeCal....