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What was Your P1NP Increase on Tymlos at 1 Month?

Osteoporosis & Bone Health | Last Active: Apr 24 3:31pm | Replies (38)
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@mayblin

Below is the info, including the CTX results. Please note that I only had one and a half treatments with Evenity and tonight will be my 29th Tymlos injection (19 full + 8 half-doses). I do not anticipate my doctor continuing to check CTX anytime soon, as Tymlos is not an anti-resorptive. Although, I haven't asked, as Tymlos is new to me for the past 1 month. I will try to remember to ask her about that next time I speak or message with her. Due to my side effects, she is testing more frequently than what I trust is typical. As soon as she started getting my results from my first round of blood & urine work at 3 weeks (all good), she told me she just submitted an order to repeat again in 3 weeks (just the CMP, P1NP, and iPTH).

Trending for P1NP
(Bone Formation Marker):
--------------------------
1) 08/28/25: Pre-Tx = 55
(CTX = 492)

2) 12/16/25: Evenity #1 = 85

3) 02/02/26: 1-Mo-Post- Evenity #2 (1/2 dose) = 52
(CTX = 544)

4) 04/13/26: Tymlos (19 full + 4 half injections) = 93

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Replies to "@mayblin Below is the info, including the CTX results. Please note that I only had one..."
mayblin | @mayblin | Apr 19 10:23am

@cathyf31 thanks for sharing those! It's interesting that your CTX increased slightly from baseline after that second (partial) dose of Evenity. Did adverse effects influence that dosing decision and, in turn (along with the bone marker info) lead to the switch to Tymlos?

As you know, Tymlos works by turning up overall bone remodeling process, which eventually affects both markers. Some doctors do tend to only check P1Np during PTH analog treatment (my endo did that until I nudged her to test both), but it's nice to get CTX alongside P1NP to see the full picture.

That jump to 93 in P1Np is a great sign. Hopefully you can gradually titrate up Tymlos to get the maximal treatment benefits. Wish you a successful journey.

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