I am 72, had ET CALR x 17 years, 8 on HU. No life-altering issues from ET per se outside of fatigue and the self-berating I do because I used to be able to run circles around everybody else. HU got rid of migraine headaches. Honestly, I was happy when I was diagnosed after years of docs blowing off symptoms as menopause and stress.

CALR patients tend to run higher platelet counts but clot less frequently than those with JAK2, so that's a teensy plus.

Keep your circulation going, reduce overall stroke risks with heart healthy diet, get your labs regularly so your platelet trends can be properly tracked and treated. If you are still working, exercise can help reduce fatigue.

You are in this for the long haul, and you may notice that symptoms increase with age. But age pretty much exacerbates everything.

Focus on what you can do. Avoid unrealistic expectations. Be vigilant about your general health. Just because you have ET doesn't mean other things can't go wrong.

My dad also had ET. He lived to be 82 and died of something else.