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What was Your P1NP Increase on Tymlos at 1 Month?
Osteoporosis & Bone Health | Last Active: Apr 24 3:31pm | Replies (38)Comment receiving replies
Hi, Cathy,
we were discussing this earlier, years ago.
I'm not much help I'm on Forteo and my P1NP took four months to move from 67 to 73 Do you really have a doctor ordering bone markers after one month. Tymlos is said to peak at one month and the remain high. When will you retest. I'd like to see more postings of bone marker number. so thanks.
https://connect.mayoclinic.org/discussion/p1np-number-on-tymlos/.
Replies to "Hi, Cathy, we were discussing this earlier, years ago. I'm not much help I'm on Forteo..."
Oh, my provider already sent a retest order for CMP, P1NP, and iPTH for 3 weeks from my last test....likely due to side effects I'm dealing with that prompted me to reduce to 1/2-dose of Tymlos, after 19 injections.
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@gently Yes!! I've had the P1NP tested 4 times, since my osteoporosis Dx last summer (Aug. 2025). First time by my PCP, so endo could have as much info as possible on my first visit. CTX has been tested twice....baseline and while on Evenity.
P1NP (Bone Formation) Trending
----------------------------
1) 08/28/25: Pre-Tx = 55
2) 12/16/25: Evenity #1 = 85
3) 02/02/26: 1-Mo-Post- Evenity #2 (1/2 dose) = 52
4) 04/13/26: Tymlos (19 full + 4 half injects) = 93