@kat260 sorry that my message hasn’t been visible for you. As i have expected he highly recommended interferon because his studies have shown significant reductions of vaf. and more importantly less incidents in terms of stroke and heart attacks. However his assumption is that 50 to 60 percent are responders. Now I am gonna try to convince my normal oncologist to find a way to go this path together, although it will be difficult because it isn’t approved yet.