← Return to Anyone living with Essential Thrombocythemia with JAK2?

Discussion
lindamarie63 avatar

Anyone living with Essential Thrombocythemia with JAK2?

Blood Cancers & Disorders | Last Active: 3 hours ago | Replies (419)
Comment receiving replies
Profile picture for claire1776 @claire1776

@janemc Thats' s interesting.....never heard that as yet. But if you're being treated, your platelets shouldn't be high but closer to normal so........?

Jump to this post

Replies to "@janemc Thats' s interesting.....never heard that as yet. But if you're being treated, your platelets shouldn't..."
janemc | @janemc | 3 days ago

@claire1776

Good question. While HU has brought down my platelet count to around 400 -- that's still the top of the "normal" range. So I have lots more platelets than someone without ET.

I also have oversized and oddly shaped platelets. This also happens when the proteins (JAK, CAL or MPL) that govern blood production mutate.

ET-distorted platelets are less able to slip through blood vessels.

This makes us more susceptible to heat and cold; contributes to the brutal headaches of ET; causes tingling and burning sensations in the extremities; and may even trigger our immune response.

VIEW AND REPLY