@loribmt Thank you for your reply! I was diagnosed last July with MDS with 5q deletion through bone marrow biopsy. I had left knee replacement in August and my recovery was almost miraculous (I had right knee replacement 2 years prior). I was doing great with no pain until I started Vidaza infusion in October. 2 weeks later I had a pulmonary embolism & 2 weeks later I passed out at church from low blood pressure. Rough start! But I’ve really been doing well since then EXCEPT for the bad pain in both knees which started with my 1st treatment. It has continued to get worse over the past 6 months. Now, my shoulders hurt too. My doctor said no one has told him that they have had bone & joint pain with Vidaza. I googled it & I think it is listed as a possible side effect. I just wonder if anyone else has experienced this.