@round5 I've also been on Lupron for 4 years and 2 years Nubeqa. I struggle with the weight issues, breast enlargement, and possibly the medicine being connected to heart issues. PSA is 0.08 and low T. Recently had PSMA Petscan and no trace of cancer outside the prostate. I've suggested to my doctor Nubeqa monotherapy and Holliday from both medicine. So far he has rejected both suggestions. How long have you been on the Nubeqa monotherapy, I would like to try to get off the Lupron also. I was first detected 10+ years ago with a biopsy of 6 and did a few years of watchful waiting. Had another biopsy a few years later and it went up to a couple cores 3+4 and I decided focal laser ablation at that time. After 3 years PSA started rising again and had another biopsy with 4+5's found in the prostate, doctor performed radiation to the pelvis area and prostate, he suspected a lymph node was in question. Was on Lupron after the radiation, a few years after that the PSA started to rise again. Been on Lupron and Nubeqa since then with undetectable PSA and no cancer detected outside the prostate.