Very interesting conversation. Thanks for bringing it up! Pun intended… With very slight bronchiectasis disease and slight to nonexistent NTMs , my most burdensome affliction is submucosal gland hyperplasia! Now I'm betwixt and between pulmonary specialists. No problem simply huffing out mucus in my morning pulmonary hygiene. Added Anoro and mucus just glides out. Prayers up and, touch wood, I am experimenting with no nebulization for a few months before my next round of pulmonary function tests, CT scans, another Sputum sample is in the works. Inflammation I think is the driving force behind changing the architecture in my lungs and I am wondering if irritating it for 2 1/2 years with saline and way too forceful huff coughing might have driven some of that inflammation…. Living with hope