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Just got my blood test results today. I have MDS

Blood Cancers & Disorders | Last Active: Apr 15 7:44pm | Replies (25)
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Profile picture for bbmj06 @bbmj06

Has anyone else had problems with joint pain while taking Vidaza (Azacitidine) infusions for MDS? I had my 2nd knee replacement 6 weeks prior to starting my treatment. My initial recovery & rehab was almost miraculous. I was doing great until I began taking treatments. Beginning with the 1st infusion I felt like I had concrete in my knees! They hurt badly and my legs feel like lead. I’m trying physical therapy now but it doesn’t seem to be working. I did not have this prior to treatment. My doctor said no one has mentioned this as a side effect but I could be in the 10% that experiences it.

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Replies to "Has anyone else had problems with joint pain while taking Vidaza (Azacitidine) infusions for MDS? I..."
katgob | @katgob | Apr 12 9:42pm

@bbmj06
I did not take that with my MDS. Is joint pain a side effect of it? I google side effects and AI gave below.
I expect someone else will respond, but i want to say i googled little during treatment, I asked my medical team. Plus, i came here to Mayo Clinic. Did you put the drug in the search box above?

Common Side Effects
Azacitidine frequently causes hematologic toxicities, including anemia, neutropenia (low white blood cells), thrombocytopenia (low platelets), and leukopenia, which increase the risk of infections and bleeding. Patients may experience fatigue, weakness, or shortness of breath due to low red blood cell counts (anemia).
Drugs.com
+3

Gastrointestinal side effects are also common, such as nausea, vomiting, diarrhea, constipation, abdominal pain, and decreased appetite. These symptoms often occur early in treatment and may improve as the body adjusts.
Drugs.com
+2

For patients receiving subcutaneous or intravenous azacitidine, injection site reactions like erythema, bruising, or pain are frequent. Oral administration may cause fatigue, dizziness, back pain, and arthralgia.
Drugs.com

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