Hi rjjb, The problems (plural) with Pramipexole is that as a dopamine angonist drug it carries the risks of both augmentation and a loss of inhibition. Augmentation is a very serious, very very unpleasant experience. Evidently in the UK (England etc) they have now banned prescribing dopamine agonists drugs for restless leg syndrome. Legally, it can no longer be prescribed to treat restless leg. The reason for the banning is that it was discovered drugs like pramipexole can causes (and has caused) disinhibition in a significant number of people involving things like sexual behaviors. On one of our RLS threads someone here in the USA wrote of experiencing this as well as compulsively spending money in an unwise manner. In the USA, dopamine agonist drugs were (past-tense) the recommended "go-to" drugs for RLS. The previous set of RLS Guidelines said they should be used as the first drug of choice to treat RLS. The NEW (2025) guidelines no longer make that recommendation. It puts people already on dopamine agonist drugs in sort of no-man's-land because as rjjb attests, these drugs work very well (until they don't). The problem of augmentation can come on at any point--days, weeks, months, years or decades after starting to take a dopamine agonist drug. "Restless leg syndrome augmentation" is easily googled and the RLS Foundation website has a very thorough, well-written description. Everyone with RLS needs to be aware of the perils augmentation presents. What a miserable, horrible experience it is! Also, it is difficult to treat. Please also google "dopamine agonists banned in the UK for restless leg." The fact that it causes lack of (sexual) inhibition is something I've only learned recently, but there are news articles about this. Although the RLS Guidelines for Treatment have been changed, not all doctors are aware of this change. Let the "buyer be aware." AND, importantly, there are other drugs that treat RLS effectively. I didn't have any symptoms last night, thanks to buprenorphine. I do not dispute that currently pramipexole is working for rjjb, but in my opinion the risks of that drug clearly outweigh the benefits. Although it works for you now, rjjb, education yourself so if augmentation starts you will recognize what is happening to you. I wish the best for you, rjjb.