Thank you. This is very helpful. The quality of life vs recurrence issue is always on my mind. I had my ovaries removed prior to treatment due to ovarian cysts that the doctors were concerned were cancerous. They were not. I suspect that the AI's mechanism of action cause problems as well as the lack of estrogen. I will speak to my oncologist. Currently I am not functioning well. It's amazing how few medical practitioners (ENT, PCP, allergist, etc.) are incapable of comprehending the potential relationship between AIs and health issues.