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Genetic Codes - PTEN loss (exons 6–9) - Any Clear Studies?
Prostate Cancer | Last Active: Apr 18 1:04pm | Replies (8)Comment receiving replies
@jeffmarc Thank you so much for sharing this study and trial. I've already shared it with my husband. We head to Duke this month and plan to discuss his genetic results and the trial with the oncologist. Right now, my husband is on Orgovyx and Nubeqa, but I'm already worried about cancer resistance. So far, capivasertib is only approved for breast cancer. This is all new to me, but just to clarify, if enrolled in the study, a person with prostate cancer may receive a placebo? This is the scary aspect - not knowing if you will win or lose in the study.
Replies to "@jeffmarc Thank you so much for sharing this study and trial. I've already shared it with..."
@scary1, not all clinical trials use placebo. More commonly with cancer treatment trials one group will get the standard treatment and the other group will get the trial treatment.
In this study, you're right that the word "placebo" is used:
- Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency (CAPItello-281) https://clinicaltrials.gov/study/NCT04493853
Reading the details, you will see that both groups (called arms) receive treatment.
1. Group 1 gets capivasertib plus abiraterone (+prednisone/prednisolone) plus androgen deprivation therapy (ADT)
2. Group 2 get placebo plus abiraterone (+prednisone/prednisolone) plus ADT
Thus both groups get effective treatment, but half the men get the study drug capivasertib added to the standard protocol to see if it improves outcomes, is safe and effective.
I hope that helps clarify and gives you more information when you meet with the doctor to discuss.
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@scary1
I understand completely. I would not want to be in a study where I might get a placebo, Especially when there’s a serious case of prostate cancer involved.
You can find out a lot more if you come to the meeting tomorrow night that’s up to you. There will be some doctors that are experts in genetic problems.