@charli7 I am 70. Everyone has to do what feels right for them, but with risk sometimes comes reward. I was also reluctant to take Avastin alone, but one of my mentors said with this disease you need to be brave. Weirdly I felt better combining Avastin with something else, which I thought might make it more effective. I started out positive, but for now I am negative for even microscopic disease. My only real side effects have been fatigue and some manageable raised blood pressure. There are no future guarantees and yes, I could have toxic side effects. I hope I will be one of the lucky ones and do my best to guard against that. No one wants to take unnecessary risks, but you and I are well aware of the long-term odds against us. In my case, I simply decided the risk of progression outweighed the risk of trying some of these drugs. Hugs!