Anastrozole and vestibular disease

Posted by ruffianfan55 @ruffianfan55, Feb 24 2:27pm

I have been on anastrozole for 3 months with minimal side effects,
Last Friday, as I was finishing up and preparing to leave work, I got a severe case of vertigo, and unrelenting vomiting. I ended up in the ER and spent the weekend in the hospital. I was diagnosed with probable BPPV (Benign Paroxysmal Positional Vertigo) and am slowly getting better. I am 70 and already had hearing loss and tinnitus, so this is not an out of the ordinary diagnosis, but I wanted to make sure that it was not related to the anastrozole. Has any one else experienced anything similar? I had no dizziness until this incident. Thank you for your help!

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Profile picture for megunique @megunique

That is very interesting and I am always happy to learn something new. We sound very similar. I am 75 and diagnosed at 69. Stage 1A IDC and had lumpectomy, radiation and anastrazole. I did not need chemo as I was right on the border line with a 27 Onco Type. Weighing the factors and possible short and long term effects and the small amount of difference in it not returning, I chose no chemo but I did do radiation and hormone therapy. Radiation as fine; it is the years after radiation when you see the changes in the soft tissue and fibrosis. But still it was an easy decision for me because I had no lymph node involvement and clean margins and I wanted to zap any possible wandering minute cells. Anastrazole was fine in the first 3.5 years; well fine except I could not sleep. But the last 1 to 1.5 years sleep deprivation was worse (the longer you are on it the more the effects are and it changed my metabolism. I do am active- strength training 3 days a week and walking another 2-3 days. But that last year it got harder and harder to control my weight. It is always a personal decision. I don't know where you live but I am blessed to be in a major medical complex and all my doctors and nurses were fabulous. I had a better diagnosis than most but still my oncologist always listened to me. I found that if you asked if the hormone blocker could cause x, y or z; she would always respond "it could". But I realized she wanted me to stay on it and if the side effects did not bother me much, she minimized it. She did offer me Tamoxifin but those side effects were undesirable and not the first choice for the cancer I had. I would say it has taken me about 6 months after I stopped the hormone blocker that my body is coming back to something more normal. Best wishes to you.

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@megunique I am so glad that you were able to complete your treatment. I had some difficulty sleeping, too, and my oncologist said “That’s not a side effect”, of course it is! Fortunately, it didn’t last, but maybe would have come back if I’d continued the drug. I so wish that the damn BPPV never happened, I wanted to take the anastrozole and thought that I could. I didn’t get an oncotype score, but the Ki-67 was 2. I take it that you didn’t have any problem with the anastrozole causing osteopenia or osteoporosis?
I hope that you can long continue your exercise routine and stay healthy! Thanks for your input!

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Profile picture for megunique @megunique

That is very interesting and I am always happy to learn something new. We sound very similar. I am 75 and diagnosed at 69. Stage 1A IDC and had lumpectomy, radiation and anastrazole. I did not need chemo as I was right on the border line with a 27 Onco Type. Weighing the factors and possible short and long term effects and the small amount of difference in it not returning, I chose no chemo but I did do radiation and hormone therapy. Radiation as fine; it is the years after radiation when you see the changes in the soft tissue and fibrosis. But still it was an easy decision for me because I had no lymph node involvement and clean margins and I wanted to zap any possible wandering minute cells. Anastrazole was fine in the first 3.5 years; well fine except I could not sleep. But the last 1 to 1.5 years sleep deprivation was worse (the longer you are on it the more the effects are and it changed my metabolism. I do am active- strength training 3 days a week and walking another 2-3 days. But that last year it got harder and harder to control my weight. It is always a personal decision. I don't know where you live but I am blessed to be in a major medical complex and all my doctors and nurses were fabulous. I had a better diagnosis than most but still my oncologist always listened to me. I found that if you asked if the hormone blocker could cause x, y or z; she would always respond "it could". But I realized she wanted me to stay on it and if the side effects did not bother me much, she minimized it. She did offer me Tamoxifin but those side effects were undesirable and not the first choice for the cancer I had. I would say it has taken me about 6 months after I stopped the hormone blocker that my body is coming back to something more normal. Best wishes to you.

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@megunique hello, I am interested in your observations. I am struggling on Anastrozole but trying to persevere ( my diagnosis very similar to your own) . One of my main concerns is that some of the side effects may not go away when I eventually complete treatment, as this is sometimes referenced in the literature. Your post has been helpful to me in that it has made me feel there may be ‘ light at the end of the tunnel’. Best wished to you.

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