I had fatigue initially but after being on hydroxyurea for 6 months (500 mg day) and platelets in 450 to 550 range, I am no longer feeling fatigued. I do walk everyday and take care of my large yard and house. At age 86, I am pretty happy with how I feel. I do take baby aspirin and was diagnosed over a year ago with Jak2 mutation. My doctor does not refer to my ET as "cancer."