@carolgk Good morning? Thank you for mentioning Vonjo. I will ask my oncologist about it. I have both Myelofibrosis and Erdheim Chester Disease and am on Cotellic from Genentech. It saved me. I had lost 50 pounds - went from around 188 down to 138. After taking Cotellic, immediately got back to around 170 (perfect weight) and most symptoms disappeared. Hope this info helps you. Also … had horrendous thoracic itching years ago. Low dosage Xanax immediately stops it. I take .25 mg Alprazolam (generic Xanax) at night. Zero itching. Maybe try that!