← Return to Anyone change from methotrexate to leflunamide? Side effects?

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@lgreg

Yes - I have noticed significant fatigue after 3 months on Methotrexate single agent and eventually stopped the drug. My doctors were saying that Methotrexate could not do that, but that type of deep fatigue with dizziness and brain fog went away after drug discontinuation. I still think those symptoms were related to Methotrexate.

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Replies to "@lgreg Yes - I have noticed significant fatigue after 3 months on Methotrexate single agent and..."

@altabiznet I was so desperately weak and fatigued and felt positively ill from the inside with methotrexate. Changed to
Leflunomide and absolutely fine from the start. Helped with feet pain, psoriatic arthritis symptoms.

@altabiznet thank you for response. My rheumatologist thought methotrexate could be the culprit. It says fatigue is a side effect in several medical sites on line. I’m hoping!!!