Finished radiaiton therapy and 18 months of orgovyx

If you just finished 18 months of Orgovyx It is a little late for getting your first PSA test. I’ve been getting test every month since I’ve been on ADT whether it was Lupron or Orgovyx Because some people become resistant to the drugs And the PSA starts rising.

Waiting one more month isn’t gonna make any difference

I had it tested and my Testosterone was low during treatment. But I am talking about when should I have it tested after the treatment and stopping orgovyx.

@donald76
Testosterone comes back pretty quick when you’re on Orgovyx. I personally would want to be tested every month, but it may take two or three months before your testosterone comes back enough for your PSA to rise. Then again, some studies have shown when it hits 50 it can affect your PSA.

Here’s some information on how quickly the testosterone comes back after stopping Orgovyx.

In the HERO study, relugolix demonstrated sustained testosterone suppression superior to that of leuprolide acetate (97% vs 89%; difference 7.9% [95% confidence interval, 4.1–12%; p < 0.001]).

Men (N = 934) were randomized (2:1) to receive relugolix 120 mg orally daily or leuprolide acetate injections every 12 wk for 48 wk.

Overall, 74 of the 137 men in the relugolix cohort recovered to testosterone >280 ng/dl, with a median time to recovery of 86.0 d (95% CI, 65.0–92.0), versus two of the 47 men in the leuprolide cohort, with a median time to recovery of 112.0 d
https://www.sciencedirect.com/science/article/pii/S2588931123002900

Yes, but since we all react differently to hormones, a month might not be long enough for you; so your first PSA may not be indicative of anything.
18 months is a fairly long time on ADT so even though the drug is cleared from your body, its effects may linger.
But your doctor is looking to see if there’s any rise at all from your previous reading, which was probably taken when you started Orgovyx, right?
I was on it for 6 months and never had bloodwork done in that time span, but maybe your experience was different.
Phil

My RO did not want a PSA test until 6 mos following completion of radiation.

Salvage radiation completed in May 2023. Orgovyx completed June 2023.
1st PSA test Nov 2023.

Best wishes.

@heavyphil Thanks I think you are correct. In any case I will follow my Doctors advice.

@michaelcharles
My first PSA following salvage radiation was at three months. It dropped down to undetectable. It did start rising again 18 months later.

Were you on ADT?