@hudson2019 Just a nosy question, so feel free to ignore: If you are in the States, how are you paying for Besremi? It is off-label for ET, and most insurance companies balk at paying for it unless a) you are of childbearing years, b) your doc documents unbearable side effects from HU (leg ulcers, for ex), c) the manufacturer provides a hardship coupon of some sort, or d) you are wealthy enough to pay out of pocket.

Are there tricks? I have had ET for 17 years, and I do wonder what happens if HU (which still works fine for me) stops working or turns on me.