@tillymack She did not. But here’s what it says on Mayoclinic.com under Proper Use section.

“ Peel off the backing from the patch and apply the patch to a clean, dry, and hair-free area of the lower stomach or upper buttock area. This area must be free of powder, oil, or lotion for the patch to stick on to your skin.”
https://www.mayoclinic.org/drugs-supplements/estradiol-transdermal-route/description/drg-20075306