@canart69 I am not sure my experience with R-Chop will help. I was diagnosed with Large B Cell Non-Hodgkin Lymphoma in 2019. It was stage 1, but it was an aggressive form of cancer. I was 67 at the time with no other health issues. In fact, all the tests I had prior to figuring out my diagnosis were met with questions like "I have looked at your medical history. There is nothing there. Why are you here?" But the biopsy did indicate cancer but more importantly, it had not spread yet. The only other issue I had was that the tumor, located along my hairline, had eroded the skull bone, exposing my brain. Further tests prior to starting my treatments indicated there was no cancer in my brain. Since it was such an early stage, my hematology team recommended R-Chop. I wound up with 6 treatments, each 3 weeks apart. In between, it was recommended that I have three separate in-hospital treatments of Methotrexate. The research I had done on Methotrexate scared me and I hesitated adding that part of the treatment. I did have all three treatments which was explained to me that it was just a precaution to make sure any lingering cancer cells were flushed completely out of my system. The R-Chop treatments were rough but, in the end, they were worth it. After 3 treatments, my PET scan showed the tumor was gone but I still continued with the three remaining treatments out of an abundance of caution. There were numerous side effects, most of which resolved themselves once I was done with my treatments. One of the side effects during my treatments was that I lost my voice. Once the treatments were completed, my voice returned but if I talk too much or too long, usually about 5 minutes straight, my voice becomes scratchy, sore, and I start to cough. I can live with that. I also had severe acid reflux. In my 67 years, I never even had so much as a mild case of heartburn. It was tough thing to treat since anything that would normally be prescribed for this would interact negatively with the R-Chop cocktail. But with the help of a pharmacist, they came up with a plan for me that worked. The other issue I have found is neuropathy in my leg following total knee replacement and, in my foot, following a bone fusion. That numbness has continued now, even 5 to 6 years after those surgeries, which were both following cancer treatment. Restless leg became an issue while doing R-Chop. What I find is that walking during the day helps a lot to limit, and usually eliminating, any trouble with sleeping at night. I am going on 7 years cancer free, or as my doctor tells me, I am cured of cancer. I am no longer at any more risk than the average person of a reoccurrence. If you trust your cancer team, they are going to do what they believe is the best course of treatment for you. I had a tremendous support system while going through my treatments. I have a cousin who is a nurse that I could talk to when I found myself conflicted about what decision to make, especially when it came to the methotrexate treatment. I did have to wait at least 6 months following my last treatment before my doctor would allow me to have knee replacement surgery. Honestly, that may be one question to ask your doctor. How long should you wait once you are done with your cancer treatments before having any other surgeries. Having trouble moving after sitting or lying down is another issue I have but for me, I think it is more about arthritis. Arthritis pain following my cancer treatments seems to be more intense. R-chop, from what I have researched, can damage nerve endings. Your difficulty moving after sitting or lying down may be normal, but exercise will help. Chemo is very hard, but the alternative is worse. If you trust your doctor, don't be afraid to ask a lot of questions. I have been so lucky to have a team of doctors, nurses, nurse practitioners, etc. that seem to want what is best for me. They have taken the time to answer all of my questions, listened to my concerns, offered a lot of good advice and suggestions, and allowed me to vent when I needed to vent. If you have the same relationship with your cancer team, trust that what they are suggesting is in your best interest. Hang in there and good luck to you.