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Optimal Duration of Hormone Therapy

Prostate Cancer | Last Active: 11 hours ago | Replies (51)
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Profile picture for northoftheborder @northoftheborder

@heavyphil Yes, doublet therapy (adding an ARSI) significantly postposes castrate-resistance.

I don't quite get the "longer-term ADT leads to castrate resistance" fear.

If I had two fires in my house, a big one blazing away (castrate-sensitive cancer) and a little one smouldering somewhere I couldn't get to (a few cells that have started to develop castrate-resistance), I wouldn't tell firefighters to let the big fire burn the house down now to prevent the little one from possibly spreading in a few years. 😕

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Replies to "@heavyphil Yes, doublet therapy (adding an ARSI) significantly postposes castrate-resistance. I don't quite get the "longer-term..."
heavyphil | @heavyphil | Mar 13 3:15pm

@northoftheborder There have been many posts during my time here, claiming - or at least suggesting - that the longer the duration of ADT, the greater the chance that the cells will become castrate resistant.
But @jeffmarc posted a communication just last week I believe, in which Dr. Wasserug said that his research shows that the earlier you are on ADT, the more successful you will be in avoiding castrate resistance.
It seems that the more PCa cells are allowed to proliferate, the more some can mutate into the resistant form.
Jeff, if you are seeing this post maybe you can chime in and straighten out the mess of an explanation I am trying to give?
I tried searching for that thread but was unsuccessful. Thanks!
Phil

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