Connect
← Return to Optimal Duration of Hormone Therapy
Discussion
Optimal Duration of Hormone Therapy
Prostate Cancer | Last Active: 33 minutes ago | Replies (53)Comment receiving replies
I'm in the opposite situation. For metastatic prostate cancer, the current expectation is that we're ADT "lifers."
Maybe that didn't matter up to just a few years ago, when life expectancy for metastatic prostate cancer was at best 3–5 years after diagnosis, but now that new treatments like doublet or triplet therapy, MDT, etc have many of us living far longer (possibly *decades* longer), we suddenly have to take a new look at the risks of long-term ADT.
I'm closely monitoring the LIBERTAS trial, which is reevaluating whether ADT holidays might also work for mCSPC now that we have doublet therapy (which didn't exist back in 2013, when the PR.7 and SWOG findings came out). The first survival and progression results are due out this fall. 🤞
Replies to "I'm in the opposite situation. For metastatic prostate cancer, the current expectation is that we're ADT..."
@northoftheborder my husband was told he will be on ADT for the rest of his life too (stage 4 metastatic).
He will have bloodwork and bone scans every 3-6 months.
Connect
@northoftheborder Well, if you couple that with Dr Weisserug’s (sp?) recent work on ADT, it seems now that being on ADT long term - or even being a lifer - does not lead to castrate resistance, one of the main reasons for these controversial holidays.
As @jeffmarc points out, being on ADT is hard work; there’s the lure of saying “screw it, I’m gonna die anyway so let’s eat, drink and be merry” and I totally get that mindset.
On the other hand, the disciplined approach of controlling blood pressure/diabetes with daily exercise and diet WILL keep you alive for many years.
It’s really a choice made early on and the results speak for themselves. My brief stint of 6 months on ADT gave me no ill effects because I watched what I ate religiously and I exercised like a madman. Could I do that for the rest of my life?? I don’t know if I could and I hope I never have to find out. Best,
Phil